Entrance hall of the ICMS Workshop

Mathematical Modelling and Analysis of Cancer Invasion of Tissues

Mar 26, 2007 - Mar 30, 2007

West Park Conference Centre, Dundee

Organisers

Name Institution
Chaplain, Mark University of St Andrews

Short Report

Elucidating the complex interplay of factors regulating tissue level phenomena via lower level cell-cell and cell-matrix interactions has emerged as a major scientific challenge in the post-genomic era, generating a great deal of interest in what is now called “Systems Biology”. In this general area of research, mathematical modelling of cancer growth is now a well-established field in its own right. Predicting how cancers develop, grow and spread and how they are best treated is providing many challenging and novel problems for applied mathematicians.

The principal objective of this workshop, with its scientific and mathematical focus on the modelling and analysis of cancer invasion and metastasis, was to provide a deeper understanding of the links between intracellular processes and cancer cell population dynamics through the use of multiscale analysis, mathematical modelling and numerical/computational techniques.

With recent advances in analytical and computational tools and techniques, mathematical models of cancer growth are becoming ever more sophisticated, accurate, quantitative and predictive. The plenary talks at the Workshop demonstrated the “state-of-the-art” in this field and generated much fruitful discussion amongst the participants. Modelling in this area has evolved to a point where many of the mathematical models are capable of generating predictions which can be tested experimentally. The Workshop was highly stimulating for all participants and proved to be a success, both scientifically and “socially”.

Participants list and links to available presentations are further down this page.

Download the pdf file of the full report

 

Arrangements

Venue
The workshop will be held in the Balbeggie Room of The West Park Conference Centre, 319 Perth Road, Dundee, DD2 1NN. For a map showing the location of the West Park Centre, visit http://www.multimap.com/ and enter the post code DD2 1NN.

Information about travel to the West Park Centre from Dundee is included in this PDF file .

Accommodation
Participants (other than the 15 invited speakers) are asked to make their own accommodation arrangements. Please click here for a PDF file of hotels and bed and breakfast establishments in Dundee. Invited speakers will be informed of their hotel arrangements by email.

Registration
For those arriving in Dundee on Sunday 25 March, there will be an evening buffet supper in the West Park Centre. Please make your way to the restaurant where the buffet will be served from 19.00 until 20.30. During this informal gathering you will be able to register for the workshop. Anyone unable to register that evening may do so between 08.30 and 09.00 on Monday morning.

Programme
The Programme is now finalised. If you are to give a contributed talk please check the Programme to find the date and time of your talk. Please note that there is a free afternoon on Wednesday 28 March.

Audio/Visual facilities
The Balbeggie Room will be equipped with a data projector, a laptop, an overhead projector and flipcharts.

Internet and Email facilities
Internet access will be available in the Balbeggie and also at Dundee University, approximately a 10-15 minute walk from the West Park Centre.

Catering
A buffet supper will be available between 19.00 and 20.30 on Sunday 25 March.

Tea and coffee will be served during each of the breaks listed in the Programme.

Lunch will be provided between 12.30 and 14.00 from Monday to Friday in the restaurant of the West Park Centre.

On Thursday 29 March, there will a workshop dinner at Jimmy Chungs, a local Chinese Restaurant.

Financial Matters
Lunches, daytime refreshments and the 2 evening meals (see above) will be provided at no cost to participants.

For all participants (excluding the 15 invited speakers), we are able to offer reimbursement, after the event, of up to 150.00 GBP to cover a portion of accommodation and travel costs. You will be given a claim form at the workshop. Please note that receipts are required for any items claimed – we are unable to reimburse any unreceipted items. Reimbursement will be in the currency of your choice, directly into your bank account, so you may wish to have a note of your bank details (including IBAN or routing number) with you, should you wish to submit your claim at the end of the workshop, rather than sending it to ICMS.

Information regarding collection of the 30.00 GBP ICMS registration fee will be sent to participants by email (excluding the 15 invited speakers).

Programme

Monday 26 March
08.30 - 09.00Registration
09.00 - 10.00Nicola Bellomo (Politecnico di Torino)
From the theory of modules to multi-scale cancer modelling
10.00 - 10.30Coffee/Tea
10.30 - 11.30Miroslaw Lachowicz (Warsaw University)
Modelling of cancer invasion at the microscopic scale
11.30 - 12.30Yannis Kevrekidis (University of Princeton)
Equation-free modelling for complex systems
12.30 - 14.00Lunch
14.00 - 14.30Eugen Mamontov (University of Gothenburg)
Oncogenic hyperplasia caused by combination of various factors: a decision-support software for radionuclide therapy
14.30 - 15.00Gabriela Litcanu (University of Witten-Herdecke)
Mathematical modelling of cell-matrix interaction
15.00 - 15.30Zhian Wang (University of Alberta)
Pattern formation for a volume filling chemotaxis model
15.30 - 16.00Anna Marciniak-Czochra (University of Heidelberg)
Multi-scale modelling of early lung cancer progression
16.00 - 16.30Tea

Tuesday 27 March
09.00 - 10.00Angela Stevens (University of Heidelberg)
Alignment and orientational aggregation
10.00 - 10.30Coffee/Tea
10.30 - 11.30Thomas Hillen (University of Alberta)
Mathematical modelling of cell movement in fibre tissues
11.30 - 12.30Hans G Othmer (University of Minnesota)
A hybrid model for tumour growth
12.30 - 14.00Lunch
14.00 - 14.30Ignacio Ramis-Conde (University of Dundee)
Influence of the E-Cadherin - β-Catenin pathway in cancer invasion and tissue architecture: a mathematical multi-scale approach
14.30 - 15.00Steven McDougall (Heriot-Watt University)
Simulating chemotherapy treatment efficacy: the impact of adaptive vascular architecture
15.00 - 15.30Paul Macklin (University of California, Irvine)
Nonlinear simulation of centimetre-scale tumour growth into realistic tissue
15.30 - 16.00Tea

Wednesday 28 March
09.00 - 10.00Alexander Anderson (University of Dundee)
Tumour morphology and mutation driven by microenvironment selection: insights from a hybrid mathematical model
10.00 - 10.30Coffee/Tea
10.30 - 11.30Vito Quaranta (Vanderbilt University Medical Center)
Mathematics-driven experimentation: validating mathematical model simulations with mouse models of cancer invasion
11.30 - 12.30Avner Friedman (Ohio State University)
Multi-scale model of tumour growth
12.30 - 14.00Lunch
14.00 onwardsFree afternoon

Thursday 29 March
09.00 - 10.00Robert A Gatenby (University of Arizona)
The roles of microenvironmental hypoxia and acidosis in carcinogenesis, from mathematical models to clinical observations
10.00 - 10.30Coffee/Tea
10.30 - 11.30Philip Maini (Oxford University)
Modelling multi-scale aspects of cancerous tumour growth
11.30 - 12.30Helen Byrne (University of Nottingham)
Multiscale modelling of colorectal cancer
12.30 - 14.00Lunch
14.00 - 14.30Marine Aubert (IMNC, Université Paris VII-Paris XI)
Modelling the interactions between glioma cells during migration
14.30 - 15.00Benjamin Ribba (University of Claude Bernard Lyon 1)
Towards the development of a numerical platform for tumour growth simulation
15.00 - 15.30Philip Gerlee (University of Dundee)
Stability analysis of a hybrid cellular automaton model of solid tumour growth
15.30 – 16.00Heiko Enderling (Tufts University)
Novel mathematical models of breast cancer development - implications for treatment design
16.00 - 16.30Alf Gerisch (University of Halle)
Taxis-driven instability in a model of cancer cell invasion of tissue
16.30 - 17.00
Tea
19.00Workshop dinner at ‘Jimmy Chung’s Chinese Restaurant’.
Dress informal.

Friday 30 March
09.00 - 10.00John Lowengrub (University of California, Irvine)
Multi-scale models of solid tumour growth and angiogenesis
10.00 - 10.30Coffee/Tea
10.30 - 11.30Luigi Preziosi (Politecnico di Torino)
Mechanical aspects of tumour growth
11.30 - 12.30Jonathan Sherratt (Heriot-Watt University)
Modelling cell adhesion in cancer
12.30 - 14.00Lunch
14.00 - 15.30Open Discussion Session
15.30 - 16.00Tea

 

Presentations:

Presentation Details
Anderson, Alexander
Tumour morphology and mutation driven by microenvironment selection: insights from a hybrid mathematical model
View Abstract Down
Aubert, Marine
Modelling the interactions between glioma cells during migration
View Abstract Down
Bellomo, Nicola
From the theory of modules to multiscale cancer modelling
View Abstract Down
Byrne, Helen
Multiscale modelling of colorectal cancer
View Abstract Down
Enderling, Heiko
Novel mathematical models of breast cancer development - implications for treatment design
View Abstract Down
Friedman, Avner
Multiscale models of tumours
View Abstract Down
Gatenby, Robert A
The roles of microenvironmental hypoxia and acidosis in carcinogenesis, from mathematical models to clinical observations
View Abstract Down
Gerisch, Alf
Taxis-driven instability in a model of cancer cell invasion of tissue
View Abstract Down
Gerlee, Philip
Stability analysis of a hybrid cellular automaton model of solid tumour growth
View Abstract Down
Hillen, Thomas
Mathematical modelling of cell movement in fibre tissues
View Abstract Down
Kevrekidis, Yannis
Equation-free modelling for complex systems
View Abstract Down
Lachowicz, Miroslaw A
Modelling of cancer invasion at the microscopic scale
View Abstract Down
Litcanu, Gabriela
Mathematical modelling of cell-matrix interaction
View Abstract Down
Lowengrub, John
Multiscale models of solid tumor growth and angiogenesis
View Abstract Down
Macklin, Paul
Nonlinear Simulation of Centimeter-Scale Tumor Growth into Realistic Tissue
View Abstract Down
Maini, Philip
Modelling multiscale aspects of cancerous tumour growth
View Abstract Down
Mamontov, Eugen
Oncogenic hyperplasia caused by combination of various factors: A decision-support software for radionuclide therapy (Authors: E. Mamontov, K. Psiuk-Maksymowicz, A. Koptioug)
View Abstract Down
Marciniak-Czochra, Anna
Multiscale modelling of early lung cancer progression
View Abstract Down
McDougall, Steven
Simulating chemotherapy treatment efficacy: the impact of adaptive vascular architecture
View Abstract Down
Othmer, Hans G
A hybrid model for tumour growth
View Abstract Down
Preziosi, Luigi
Mechanical aspects of tumour growth
View Abstract Down
Quaranta, Vito
Mathematics-driven experimentation: Validating mathematical model simulations with mouse models of cancer invasion
View Abstract Down
Ramis Conde, Ignacio
Influence of E-Cadherin - beta - Catenin pathway in cancer invasion and tissue architecture: A mathematical multi-scale approach
View Abstract Down
Ribba, Benjamin
Towards the development of a numerical platform for tumour growth simulation
View Abstract Down
Sherratt, Jonathan
Modelling cell adhesion in cancer
View Abstract Down
Stevens, Angela
Alignment and orientational aggregation
View Abstract Down
Wang, Zhian
Pattern formation for a volume filling chemotaxis model
View Abstract Down

Participants

Name Institution
Anderson, Alexander H. Lee Moffitt Cancer Center & Research Institute
Astanin, Sergey Politecnico di Torino
Aubert, Marine IMNC, Université Paris 7
Basanta Gutierrez, David Technische Universität Dresden
Bellomo, Nicola Politecnico di Torino
Bunimovich, Svetlana Tel-Aviv University
Byrne, Helen University of Oxford
Cappuccio, Antonio IAC (Institute for Application of Computing, Rome)
Chaplain, Mark University of St Andrews
Davidson, Fordyce University of Dundee
de Franciscis, Sebastiano Universidad de Granada
Enderling, Heiko H. Lee Moffitt Cancer Center & Research Institute
Figueiredo, Isabel University of Coimbra
Friedman, Avner Ohio State University
Gatenby, Robert A University of Arizona
Gerisch, Alf Technische Universität Darmstadt
Gerlee, Philip University of Dundee
Hatzikirou, Babis Dresden University of Technology
Hillen, Thomas University of Alberta
Kevrekidis, Yannis University of Princeton
Lachowicz, Miroslaw A Warsaw University
Li, Natasha University of Oxford
Litcanu, Gabriela University Witten-Herdecke
Lolas, Georgios Technical University of Dresden
Lowengrub, John Univeristy of California, Irvine
Macklin, Paul University of California, Irvine
Maini, Philip University of Oxford
Mamontov, Eugen Gothenburg University
Marciniak-Czochra, Anna University of Heidelberg
McDougall, Steven Heriot-Watt University
Mistry, Hitesh University of Dundee
Morales Rodrigo, Cristian Warsaw University
Othmer, Hans G University of Minnesota
Painter, Kevin Heriot-Watt University
Piotrowska, Monika Joanna University Witten-Herdecke
Preziosi, Luigi Politecnico di Torino
Psiuk-Maksymowicz, Krzysztof Göteborg University
Quaranta, Vito Vanderbilt University School of Medicine
Ramis Conde, Ignacio University of Dundee
Rejniak, Katarzyna H. Lee Moffitt Cancer Center & Research Institute
Ribba, Benjamin Université Claude Bernard Lyon 1
Sherratt, Jonathan Heriot-Watt University
Stamper, Johanna University of Nottingham
Stéphanou, Angélique Laboratoire TIMC-IMAG, UMR CNRS 5525
Stevens, Angela Heidelberg University
Szymańska, Zuzanna Warsaw University
van Leeuwen, Ingeborg University of Nottingham
Verdier, Claude Laboratoire de Spectrométrie Physique - UMR5588
Wang, Zhian University of Alberta