Scientific organisers
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Rachel Bennett , University of Bristol
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Robijn Bruinsma , University of California, Los Angeles
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Buddhapriya Chakrabarti , University of Sheffield
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Tanniemola Liverpool , University of Bristol
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Reidun Twarock , University of York
About:
This interdisciplinary meeting brought together theoreticians and experimentalists working on viruses and protein nano-containers, to stimulate collaborations in the following areas:
1. Design principles of natural and artificial protein containers
2. Kinetics of protein container assembly
3. Cargo/genome packaging and release
4. Evolutionary optimisation of container geometry
5. Applications in virus nanotechnology
Scam Warning
We are aware of a very convincing scam targeting participants in mathematical research events. These scammers may telephone or email you and tell you that they are organising accommodation in Edinburgh for you on behalf of ICMS. If you are approached by a third party (eg travellerpoint.org) asking for booking or payment details, please ignore. ICMS will never ask you for credit/debit card information. If we are booking accommodation for you, the email will come from ICMS, never a third party. It seems the scammers are picking up speaker names from workshop webpages so please be vigilant if you are attending other workshops elsewhere next year. This is not the only workshop and ICMS is not the only institute to be targeted. These scammers were prolific before the pandemic and would now appear to be back in business.
Programme:
| MONDAY 13 NOVEMBER 2023 | ||
| Registration and Refreshments | ||
| Welcome and Housekeeping | ||
| William Gelbart, UCLA | IN CELLULO versus IN VITRO RECONSTITUTION OF RNA-SPECIFIC VIRUS-LIKE PARTICLES | |
| Dek Woolfson, University of Bristol | Rationally and computational design of functional protein barrels | |
| Farzad Fatehi, University of York | Geometry as a key to the virosphere – from viral infections to virus nanotechnology | |
| Refreshments | ||
| Roya Zandi, University of CA, Riverside | The role of flexibility of capsid proteins in the symmetry of viral shells | |
| Danielle Tullman-Ercek, Northwestern University | Designing with nanoscale building blocks: engineering self-assembling protein superstructures for applications in vaccines, drug delivery and biochemical production | |
| Lunch | ||
| David Bhella, MRC - University of Glasgow Centre for Virus Research | Capsid stability and receptor mediated priming in calicivirus entry | |
| Alexander Borodavka, University of Cambridge | How do Viruses Use RNA Granules and RNA Chaperones to Assemble Their Segmented Genomes? | |
| Refreshments | ||
| Uri Raviv, The Hebrew University of Jerusalem | Mechanism of Virus Capsid Assembly | |
| Erwin Frey, Ludwig-Maximilians-Universitaet Muenchen | The time complexity of self-assembly | |
| Welcome Reception, hosted at ICMS | ||
| TUESDAY 14 NOVEMBER 2023 | ||
| Seth Fraden, Brandeis University | Hierarchical assembly is more robust than egalitarian assembly in synthetic capsids | |
| Ard Louis, University of Oxford | Does self-assembly design have a built-in Occam's razor? | |
| Guillaume Tresset, Université Paris-Saclay | Antivirals alter the kinetic assembly pathway and elastic properties of Hepatitis B virus capsids | |
| (contributed) Paddy Royall, ESPCI Paris | Resolving Challenges in Self-Assembly with Nano Real Space Analysis | |
| Refreshments | ||
| Carol Teschke, University of Connecticut | Using a scaffold to build a virus | |
| Paul van der Schoot, Eindhoven University of Technology | Electrostatic Theory of the Acidity of the Solution in the Lumina of Viruses and Virus-Like Particles | |
| Lunch | ||
| Michael Hagan, Brandeis University | Enhancing self-assembly with time-dependent protocols and liquid-liquid phase separation | |
| Jodi Hadden-Perilla, University of Delaware | Mechanistic insights into HBV capsid assembly and its inhibition revealed by all-atom MD simulations | |
| Refreshments | ||
| Richard Bingham, University of York | Virus-like particles, packaging signals and assembly pathways. | |
| David Wales, Cambridge University | Energy landscapes for Self-Assembly | |
| Poster session | ||
| WEDNESDAY 15 NOVEMBER 2023 | ||
| Ulrich Schwarz, Heidelberg University | Competition between efficiency and selectivity in container assembly | |
| Charlotte Uetrecht, CSSB, Hamburg & University of Siegen | Flying viruses - mass spectrometry meets X-rays | |
| Eric Dykemann, University of York | Exploring the effects of non-equilibrium processes on virus assembly in vivo | |
| Refreshments | ||
| Alan Rein, National Cancer Institute | Pathway and Thermodynamic Analysis of HIV-1 Immature Particle Assembly | |
| Juan Perilla, University of Delaware | The Hiv-1 Capsid Mechanoelastic Properties Regulate Nuclear Import And Uncoating. | |
| Lunch | ||
| Shenshen Wang, University of California, Los Angeles | Non-equilibrium physics of antigen recognition | |
| (contributed) Jure Dobnikar, Chinese Academy of Sciences | Self-assembly of viral capsids and packing of genome | |
| Refreshments | ||
| Orlando Guzman, Universidad Autonoma Metropolitana - Iztapalapa (Online) | Kinetic model of high packaging selectivity of the dimeric HIV-1 genomic RNA | |
| Rees Garmann, San Diego State University | Capsid assembly and genome packaging in a simple plus-strand RNA virus | |
| (contributed) Sam Clark, University of York | Recoding mRNA therapeutic cargoes for efficient viral packaging | |
| Wouter Roos, Rijksuniversiteit Groningen | Single-molecule approaches to study viral self-assembly in real-time | |
| THURSDAY 16 NOVEMBER 2023 | ||
| Don Hilvert, ETH Zürich | Evolving virus-like assemblies in the lab | |
| Jonathan Heddle, University of Durham | Towards dynamic artificial protein containers | |
| Joe Grove, MRC-University of Glasgow Centre for Virus Research | Using machine learning to map form and function across the virome | |
| (contributed) Andrew Shevchuk, Imperial College London | Direct label-free visualisation of virus particle assembly | |
| Refreshments | ||
| Ed Hutchinson, MRC-University of Glasgow Centre for Virus Research | Bags, not boxes: integrative modelling of enveloped viruses | |
| (contributed) Alex Evilevitch, Lund University | Temperature-induced DNA density transition in phage lambda capsid revealed with contrast matching SANS | |
| Lunch | ||
| Marco Vignuzzi, A*STAR ID Labs | Experimental evolution to uncover biological functions, essential genomic sequences, intramolecular partners and virus-host interactions. | |
| (contributed) Connie Chang, Mayo Clinic | Single cell virology using drop-based microfluidics | |
| Refreshments | ||
| Jennifer McManus, University of Bristol | Rational design of protein phase transitions- equilibrium and non-equilibrium |
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| (contributed) Rebecca Chandler-Bostock, University of Leeds | Genome-regulated Assembly of a ssRNA Virus May Also Prepare It for Infection | |
| Wilson Poon, University of Edinburgh | Disassembly of viruses | |
| Workshop Dinner, location tbc | ||
| FRIDAY 17 NOVEMBER 2023 | ||
| Tanniemola Liverpool, University of Bristol | Flexibility and defects in the soft self-assembly of synthetic biological systems | |
| Alena Khmelinskaia, Ludwig Maximilian University of Munich | Exploring the protein assembly space with structural flexibility | |
| Robijn Bruinsma, University of California | Genome Selection by RNA Viruses | |
| Bogdan Dragnea, Indiana University at Bloomington | The Bright Side of Small Icosahedral Virus-like Particles | |
| Packed lunch | ||
| End of Workshop |